Chromosome segregation errors generate a diverse spectrum of simple and Biology Diagrams Chromosome mis-segregation induces rapid p21/p53 activation. To investigate the immediate cellular consequences of aneuploidy, we used a rapid and tunable cellular model to induce chromosome mis Errors in the process result in chromosome missegregation, a significant consequence of which is the emergence of aneuploidy—characterized by an imbalance in chromosome number—and the e Schematic representation of the experimental approaches used for the study of the 1st S-phase after induction of chromosome missegregation. A short EdU pulse was performed before cell harvest in
These contradictory effects are also observed in mouse models of chromosome instability (CIN). CIN can inhibit and promote tumorigenesis. Recent work has provided insights into the cellular consequences of CIN and aneuploidy. Chromosome mis-segregation per se can alter the genome in many more ways than just causing the gain or loss of chromosomes.
Recent insights into the causes and consequences of chromosome mis ... Biology Diagrams
Mitotic cells face the challenging task of ensuring accurate and equal segregation of their duplicated, condensed chromosomes between the nascent daughter cells. Errors in the process result in chromosome missegregation, a significant consequence of which is the emergence of aneuploidy-characterized … These structures are prone to rupture, with significant consequences for genomic stability and cellular function. One primary cause of micronuclei formation is chromosome missegregation during mitosis. Errors in spindle assembly, kinetochore-microtubule attachments, or spindle checkpoint defects can result in whole chromosomes failing to MMCT permits studying the long-term effects of aneuploidy as it allows the generation of cells carrying additional chromosomes, 37-40 although the early consequences immediately following a chromosome missegregation event will almost certainly have been missed after the long experimental procedure to create the cells-of-interest.
Consequences of Non-Random Chromosome Segregation Errors 5.1. Karyotype Evolution in Cancer Farr C.J. Increased missegregation and chromosome loss with decreasing chromosome size in vertebrate cells. Chromosoma. 2006;115:60-74. doi: 10.1007/s00412-005-0032-6. [Google Scholar] 56. Bochtler T., Kartal-Kaess M., Granzow M., Hielscher T In Chapter 3, I contribute to work exploring the immediate consequences of chromosome missegregation in hPSCs. By inducing aneuploidy in hPSCs, we demonstrate their inherent tolerance to chromosome missegregation, as evidenced by continued proliferation without activating the p53-p21 response, contrasting with the response of normal somatic cells.
