Mechanisms of Chromosomal Instability Biology Diagrams During mitosis, duplicated sister chromatids are properly aligned at the metaphase plate of the mitotic spindle before being segregated into two daughter cells. This requires a complex process to ensure proper interactions between chromosomes and
Moreover, loss of POS3 results in prolonged mitosis, increased aneuploidy, and misaligned chromosomes near the spindle poles. Unexpectedly, we discovered a direct physical interaction and functional link between POS3 and the microtubule polymerase MICROTUBULE ORGANIZATION1 (MOR1) in regulating chromosome alignment and segregation during mitosis. Although the process of mitotic cell division has been studied intensely for more than 50 years, Whitehead Institute researchers have only now solved the mystery of how cells correctly align their chromosomes during symmetric mitosis.
Biomechanics of chromosome alignment at the spindle midplane Biology Diagrams
The Chromosome Passenger Complex (CPC) is a complex involving four proteins, which are essential to ensuring proper chromosome condensation, alignment, and segregation.
Congression of the last chromosome marks the transition to the next stage of mitosis, metaphase โ the stage at which all chromosomes are aligned at the spindle equator. Shortly after metaphase alignment, the cohesion between sister chromatids is broken, and the cell enters anaphase. Chromosome congression during prometaphase culminates with the establishment of a metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more than 100 years of research on this topic have attempted to explain chromosome Abstract During metaphase, chromosomes are aligned in a lineup at the equatorial plane of the spindle to ensure synchronous poleward movement of chromatids in anaphase and proper nuclear reformation at the end of mitosis. Chromosome alignment relies on microtubules, several types of motor protein and numerous other microtubule-associated and regulatory proteins. Because of the multitude of
kinesin motor POS3 and the microtubule polymerase MOR1 coordinate ... Biology Diagrams
Segregation of chromosomes in mitosis is preceded by chromosome reorganization into the characteristic mitotic shapes observed in most animal cells. This chromosome reorganization takes place during early mitosis (prophase and prometaphase) and involves two major structural changes.
